Home / 健康 / 健康全般 / 睡眠 / ジプレキサを飲むと眠気が現れる原因
薬

ジプレキサを飲むと眠気が現れる原因

薬

ジプレキサは、非定型抗精神病薬(第2世代抗精神薬)で、主に統合失調症の治療に使われる薬です。ただ、ジプレキサの副作用としては眠気があげられ、非常に強い眠気に悩まされている方も多いようです。

本記事では、ジプレキサの作用とジプレキサを服用すると眠気が生じる原因をご紹介します。

スポンサーリンク

ジプレキサの効果と作用

猫

ジプレキサには、気持ちの高ぶりや不安感を鎮めるほか、停滞した心身の活動を改善する作用があり、主に統合失調症の治療に使われます。ここでは、統合失調症とはどのような病気であるか、ジプレキサがなぜこの病気を改善する作用があるのかをご紹介します。

統合失調症とは?

統合失調症は、脳をはじめとした神経系に障害が生じる慢性の疾患です。10歳代後半から30歳代前半の間に発症し、徐々に進行します。

脳内の神経細胞同士の情報伝達に利用される「神経伝達物質」の異常が原因とされています。なかでも、神経伝達物質のひとつであるドーパミンの作用が過剰になると、幻覚や妄想が出現しやすくなることが知られています。

症状には大きくわけて二つ、陽性症状陰性症状があります。
陽性症状は急性期に生じることが多く、幻聴や妄想が現れ、奇妙な行動、考えの混乱、話題の飛躍などが見られます。
陰性症状は消耗期に生じることが多く、自信や自己抗力感を失い、根気や集中力が続かない、意欲がわかない、喜怒哀楽がはっきりしないなどの状態となって現れます。

ジプレキサの効果

ジプレキサの抗精神作用は、ドーパミンD2受容体、セロトニン5-HT2A受容体への拮抗作用によるものと考えられています。この作用を次にもう少し詳しく説明しましょう。

ドーパミンD2受容体にジプレキサが作用すると、神経伝達物質のひとつであるドーパミンの作用が抑制されます。統合失調症の陽性症状は、ドーパミンの作用が過剰になっていることが原因ですので、ジプレキサの作用により陽性症状が改善されるのです。

次にセロトニン5-HT2A受容体にジプレキサが作用した場合の効果をみてみましょう。セロトニンは前述のドーパミンの作用を抑制する効果があります。ジプレキサの作用によりセロトニンの働きが抑制されることで、ドーパミンの不足が解消されます。陰性症状はドーパミンの不足によるものですので、セロトニンの抑制が陰性症状の改善につながるということになります。

ここまでのご説明を簡単にまとめると、以下のようになります。
【ジプレキサの陽性症状への作用】

  • 1.ドーパミンD2受容体にジプレキサが作用
  • 2.ドーパミンの作用が抑制される
  • 3.ドーパミンの過剰により起こっていた陽性症状が改善される

【ジプレキサの陰性症状への作用】

  • 1.セロトニン5-HT2A受容体にジプレキサが作用
  • 2.セロトニンの作用が抑制される
  • 3.セロトニンによって抑制されていたドーパミンの作用が回復
  • 4.ドーパミンの不足によって起こっていた陰性症状が改善される

ジプレキサを飲むと眠気が現れる理由

前項でご紹介したように、ジプレキサはドーパミン、セロトニンといった神経伝達物質の受容体への拮抗作用により、統合失調症の症状を改善しています。

ところで、ジプレキサは多元受容体標的化抗精神薬と呼ばれていて、ドーパミンやセロトニン以外のアドレナリンa1やヒスタミンH1の受容体にも作用する薬です。ジプレキサを飲むと眠気が現れるのは、ジプレキサがヒスタミンH1受容体に作用することが原因です。

これをもう少し詳しくご説明しましょう。ヒスタミンは覚醒機能に関与する神経伝達物質です。ジプレキサが脳の中枢部位に存在しているヒスタミン受容体に作用すると、覚醒機能が低下しこれが眠気につながるのです。

よくわかる双極性障害(躁うつ病) (セレクトBOOKS)
主婦の友社
売り上げランキング: 9,280

まとめ:ジプレキサの眠気は受容体への拮抗作用によるもの

ジプレキサは多元受容体標的化抗精神薬で、ドーパミンD2受容体やセロトニン5-HT2A受容体に作用して、統合失調症の症状を改善する薬です。一方で、ヒスタミン受容体にも作用するため、ヒスタミンによる覚醒機能が低下し眠気を招くという副作用もあります。

統合失調症は病気の改善までに時間が必要となる病気であるため、服用する薬の副作用である眠気が生活に支障を来す場合もあることが考えられます。このような場合は、我慢をしたり勝手に薬の服用を中止したりせずに、主治医の先生に相談してみましょう。ジプレキサ以外の薬を処方してもらえるかもしれません。

本記事をご参考にジプレキサのもつ作用を理解し、少しでも治療の助けにしていただければ、と思います。

スポンサーリンク

Check Also

寝室

快適なベッドルームにするためのコーディネート術

一日の疲れを取るためのベッドル …

92 comments

  1. Good article. I will be facing a few of these issues as well..

  2. An outstanding share! I’ve just forwarded this onto a colleague who had been conducting a little research on this.
    And he in fact ordered me dinner simply because I stumbled upon it for him…
    lol. So let me reword this…. Thank YOU for the meal!! But yeah,
    thanks for spending some time to discuss this subject here on your web site.

  3. Very energetic article, I loved that bit. Will there be a part 2?

  4. Every weekend i used to visit this site, as i
    wish for enjoyment, for the reason that this this web site conations in fact good funny information too.

  5. I know this web page offers quality depending articles and
    other data, is there any other website which gives such stuff in quality?

  6. If some one desires expert view concerning blogging and site-building after that
    i recommend him/her to visit this weblog, Keep up
    the fastidious work.

  7. Good post. I learn something new and challenging on websites I stumbleupon every day.
    It will always be helpful to read through articles from other
    authors and use a little something from their web sites.

  8. I think everything said made a ton of sense. However, what
    about this? suppose you added a little content? I ain’t saying your information isn’t good., but suppose you added a title
    that grabbed people’s attention? I mean ジプレキサを飲むと眠気が現れる原因
    | iGotit is a little boring. You could peek at Yahoo’s home page and see how they
    create article headlines to grab viewers interested.

    You might try adding a video or a picture or two to grab people interested about everything’ve got to say.
    Just my opinion, it would bring your posts a little livelier.

  9. I like the valuable information you provide in your articles.
    I will bookmark your weblog and check again here frequently.
    I am quite certain I’ll learn many new stuff right here!
    Best of luck for the next!

  10. Have you ever considered about adding a little bit
    more than just your articles? I mean, what you say is valuable and everything.

    Nevertheless think about if you added some great images
    or videos to give your posts more, “pop”! Your content is excellent but with pics and video clips, this website could certainly
    be one of the most beneficial in its field. Wonderful blog!

  11. I am genuinely happy to read this webpage posts which includes
    tons of helpful information, thanks for providing these statistics.

  12. Woah! I’m really loving the template/theme of this blog. It’s simple, yet effective.

    A lot of times it’s very difficult to get that “perfect balance”
    between superb usability and visual appeal.

    I must say you have done a fantastic job with this. Additionally, the blog loads super fast for me on Safari.

    Superb Blog!

  13. Howdy! This blog post couldn’t be written much better! Looking at this article reminds me of my previous roommate!
    He always kept talking about this. I’ll send this post to him.
    Fairly certain he’ll have a great read. Thanks for sharing!

  14. After I initially left a comment I appear to have
    clicked on the -Notify me when new comments are added-
    checkbox and from now on each time a comment is added I recieve four emails with the exact same
    comment. Perhaps there is a way you are able to remove me from that
    service? Many thanks!

  15. Hey! I just wanted to ask if you ever have any issues with hackers?
    My last blog (wordpress) was hacked and I ended up losing months of
    hard work due to no data backup. Do you have any methods to stop hackers?

  16. I know this web site offers quality dependent articles and extra information,
    is there any other web page which gives such stuff in quality?

  17. Good way of telling, and fastidious article to take data about my presentation subject matter, which i am
    going to deliver in institution of higher education.

  18. If you want to get much from this post then you have to apply
    such strategies to your won web site.

  19. I am in fact delighted to read this blog posts
    which includes lots of helpful data, thanks for providing such statistics.

  20. Asking questions are really pleasant thing if you are not understanding something fully, except this paragraph gives fastidious understanding yet.

  21. Hello there, You have done an incredible job.
    I will definitely digg it and personally suggest to my friends.
    I am confident they’ll be benefited from this web site.

  22. I loved as much as you’ll receive carried out right here. The sketch is attractive, your
    authored subject matter stylish. nonetheless, you command
    get got an edginess over that you wish be delivering the
    following. unwell unquestionably come further formerly again as exactly the same nearly
    very often inside case you shield this hike.

  23. It’s really a cool and helpful piece of info. I’m satisfied that you simply shared this useful
    information with us. Please stay us up to date like this.
    Thanks for sharing.

  24. Have you ever thought about writing an e-book or guest authoring on other blogs?
    I have a blog based upon on the same information you discuss
    and would love to have you share some stories/information. I know
    my visitors would appreciate your work. If you’re even remotely
    interested, feel free to shoot me an e mail.

  25. Hello there! This is my 1st comment here so I just wanted to give a quick shout
    out and tell you I really enjoy reading your posts. Can you
    recommend any other blogs/websites/forums that go over
    the same topics? Thanks for your time!

  26. bookmarked!!, I really like your web site!

  27. Great post. I was checking constantly this blog and I am impressed!
    Extremely helpful information specifically the last part :
    ) I care for such info much. I was looking for this particular info for a very long time.
    Thank you and best of luck.

  28. I blog often and I seriously appreciate your
    content. This article has really peaked my interest.

    I’m going to book mark your site and keep checking for new details
    about once a week. I subscribed to your Feed as well.

  29. Good site you have got here.. It’s difficult to find high quality writing like yours nowadays.
    I really appreciate individuals like you! Take care!!

  30. I got this site from my friend who told me concerning this
    website and at the moment this time I am browsing this web site
    and reading very informative posts here.

  31. you’re actually a good webmaster. The website loading speed is amazing.
    It kind of feels that you’re doing any distinctive trick. Furthermore, The contents
    are masterwork. you’ve done a wonderful process on this topic!

  32. Good post. I’m dealing with some of these issues as well..

  33. excellent publish, very informative. I ponder why
    the other specialists of this sector do not understand this.
    You must proceed your writing. I’m sure, you have a great readers’ base already!

  34. Thank you for another wonderful post. The place else may just anyone get that type of info
    in such a perfect means of writing? I have a presentation next
    week, and I’m at the look for such information.

  35. Hi there, You have done an excellent job. I’ll definitely
    digg it and personally recommend to my friends. I am confident they will be benefited from
    this web site.

  36. Howdy just wanted to give you a brief heads up and let you
    know a few of the images aren’t loading correctly. I’m not sure why but I think its a linking issue.
    I’ve tried it in two different browsers and both show the same
    outcome.

  37. Hey very interesting blog!

  38. Tremendous things here. I am very happy to peer your article.

    Thank you so much and I am looking ahead to touch you.
    Will you please drop me a e-mail?

  39. Thanks for sharing your info. I really appreciate your
    efforts and I am waiting for your next write ups thanks once again.

  40. If some one wishes expert view on the topic of blogging and site-building after that i advise him/her
    to go to see this webpage, Keep up the nice job.

  41. This is very interesting, You are a very skilled blogger.

    I’ve joined your rss feed and look forward to seeking more
    of your wonderful post. Also, I’ve shared your site in my social
    networks!

  42. I’d like to find out more? I’d care to find out more details.

  43. If some one wants to be updated with most recent technologies therefore he must be visit this web site and
    be up to date every day.

  44. Everyone loves it when individuals come together and share
    views. Great website, continue the good work!

  45. I was recommended this web site by my cousin. I am not sure whether this post is written by him as nobody else know such detailed about my trouble.
    You are wonderful! Thanks!

  46. I got this site from my friend who shared with me on the topic
    of this website and at the moment this time I am visiting
    this site and reading very informative articles at this time.

  47. whoah this weblog is magnificent i love reading your articles.

    Stay up the good work! You recognize, many individuals are hunting round
    for this information, you could aid them greatly.

  48. Hello friends, how is all, and what you would like to say about this piece of writing, in my view its really remarkable
    in favor of me.

  49. It’s an amazing article in favor of all the online users; they will take benefit from it I am sure.

  50. This article will assist the internet visitors for setting up new weblog or even a blog from start to end.

  51. It’s perfect time to make some plans for
    the future and it is time to be happy. I have read this
    put up and if I could I wish to suggest you few interesting things
    or tips. Maybe you could write next articles regarding this article.

    I want to read more things about it!

  52. It’s very simple to find out any matter on web as compared to books,
    as I found this post at this site.

  53. I’m really impressed with your writing skills as neatly as with
    the format to your blog. Is this a paid subject
    matter or did you modify it your self? Either way keep up the excellent high quality writing, it is rare to see a great blog like this one
    today..

  54. I’m amazed, I must say. Seldom do I come across a blog that’s both educative and amusing, and
    without a doubt, you’ve hit the nail on the head.
    The problem is an issue that not enough men and women are speaking intelligently about.
    Now i’m very happy I found this during my search for something concerning this.

  55. What’s up i am kavin, its my first occasion to commenting anywhere, when i read this article i thought i could also make comment due to
    this good article.

  56. all the time i used to read smaller articles or reviews that as well clear their motive, and that is also happening with this piece of writing which I am reading
    at this place.

  57. We are a group of volunteers and starting a new scheme in our community.
    Your site offered us with valuable information to work on. You have done an impressive job and
    our entire community will be thankful to you.

  58. Normally I do not learn article on blogs, but I wish to say that this write-up very pressured me to check out and do so!
    Your writing style has been surprised me. Thanks, quite great post.

  59. I don’t even know how I ended up here, but I thought this post was great.
    I don’t know who you are but certainly you’re going to a famous blogger if you aren’t already 😉 Cheers!

  60. I do not even know how I ended up here, but I thought this post was great.

    I don’t know who you are but certainly you’re going to a famous
    blogger if you are not already 😉 Cheers!

  61. I read this paragraph fully on the topic of the resemblance of
    most up-to-date and previous technologies, it’s remarkable article.

  62. Pretty section of content. I just stumbled upon your weblog and in accession capital to assert that I acquire in fact
    enjoyed account your blog posts. Anyway I will be subscribing to your feeds and even I achievement
    you access consistently quickly.

  63. Pretty nice post. I just stumbled upon your weblog and wished to mention that I have truly
    loved surfing around your weblog posts. After all I’ll be subscribing for your rss feed and I am hoping you write
    again soon!

  64. Hello! Do you know if they make any plugins to protect against hackers?
    I’m kinda paranoid about losing everything I’ve worked hard on. Any
    tips?

  65. It’s remarkable to pay a visit this website and reading the views of all friends
    concerning this piece of writing, while I am also keen of getting experience.

  66. Heya! I just wanted to ask if you ever have any problems with hackers?

    My last blog (wordpress) was hacked and I ended up losing many
    months of hard work due to no back up. Do you have any methods to protect against hackers?

  67. Greetings from California! I’m bored to death at work so I decided
    to check out your blog on my iphone during lunch break.
    I really like the knowledge you provide here and
    can’t wait to take a look when I get home. I’m amazed at how
    quick your blog loaded on my phone .. I’m not even using WIFI, just
    3G .. Anyhow, excellent site!

  68. Heya this is somewhat of off topic but I was wanting to know
    if blogs use WYSIWYG editors or if you have to manually code with HTML.
    I’m starting a blog soon but have no coding skills so I wanted
    to get guidance from someone with experience.
    Any help would be enormously appreciated!

  69. This is really interesting, You are a very skilled blogger.
    I have joined your feed and look forward to seeking more of your
    magnificent post. Also, I’ve shared your site in my social networks!

  70. This is really fascinating, You’re a very skilled blogger.
    I have joined your rss feed and sit up for in search of extra of your
    fantastic post. Additionally, I’ve shared your web
    site in my social networks

  71. After I initially commented I appear to have clicked on the
    -Notify me when new comments are added- checkbox and now whenever a
    comment is added I recieve four emails with the exact same comment.
    There has to be an easy method you can remove me from that service?
    Kudos!

  72. Very nice post. I certainly love this site. Keep
    writing!

  73. Hmm it seems like your blog ate my first comment (it was extremely long) so I guess I’ll just sum it up what I wrote and say, I’m thoroughly
    enjoying your blog. I too am an aspiring blog writer but I’m still new to everything.
    Do you have any points for inexperienced blog writers? I’d really appreciate it.

  74. Great post. I used to be checking constantly this blog and I am inspired!
    Extremely useful information specially the remaining section 🙂 I
    care for such info much. I was seeking this particular information for
    a very long time. Thanks and good luck.

  75. Hello I am so glad I found your blog, I really found you
    by accident, while I was researching on Bing
    for something else, Anyhow I am here now and would just like to say thank you for a fantastic post and a all round entertaining blog
    (I also love the theme/design), I don’t have time to read it all at the minute but I have bookmarked it
    and also added in your RSS feeds, so when I have time I will be
    back to read a lot more, Please do keep up the fantastic job.

  76. Great article, just what I was looking for.

  77. I constantly spent my half an hour to read this blog’s articles all the time along with a mug of coffee.

  1. Pingback: Google

  2. Pingback: Google

  3. Pingback: barcode kaufen

  4. Pingback: mailing list

  5. Pingback: robert

  6. Pingback: Make Money Online

  7. Pingback: Jinaat

  8. Pingback: freddy jeans

  9. Pingback: vintage collectibles

  10. Pingback: global franchise

  11. Pingback: adam and eve toys

  12. Pingback: hands free sex toys

  13. Pingback: sex toys cleaner

  14. Pingback: adam and eve sex toys

コメントを残す

メールアドレスが公開されることはありません。 * が付いている欄は必須項目です